Female Sexual Health Treatment (Tadalafil/PT-141)

Compounded Tadalafil / PT-141 Oral Solution

This medication is a compounded oral formulation that combines two prescription treatments that support sexual function through different pathways: Tadalafil and PT-141 (bremelanotide). Tadalafil is a PDE5 inhibitor that works by increasing blood flow to the penis to help men achieve and maintain erections during sexual activity. PT-141 is a melanocortin receptor agonist that acts on pathways in the brain involved in sexual desire and arousal.

By combining both active ingredients in one compounded oral solution, patients may benefit from:

• Dual-action support: tadalafil addresses the physical (blood flow) side of erections, while PT-141 targets desire and arousal.
• Convenience: a single medication instead of multiple prescriptions.
• Personalized treatment: compounded specifically for individual patients by a licensed pharmacy.
• Extended window: tadalafil can remain effective for up to 36 hours, while PT-141 acts around the time of each dose.

Important Information:

• This is a compounded medication prepared by a licensed pharmacy. It is not an FDA-approved product. Tadalafil is FDA-approved for erectile dysfunction. PT-141 is the active ingredient in an FDA-approved medication for a different use, so its use in this formulation is off-label. Compounded medications are prescribed when commercially available options may not fully meet a patient’s needs.
• As with all PDE5 inhibitors, this medication should not be used with nitrates or certain blood pressure medicines due to the risk of dangerously low blood pressure.
• PT-141 can cause a temporary rise in blood pressure and a drop in heart rate. This medication is not appropriate for patients with uncontrolled high blood pressure or known cardiovascular disease.
• Common side effects may include nausea, headache, flushing, nasal congestion, indigestion, or muscle/back pain. Nausea is the most frequently reported side effect of PT-141.
• Some patients may notice darkening of small areas of skin, such as on the face or gums (hyperpigmentation), particularly with frequent use.
• Serious side effects are rare but can include sudden vision or hearing changes, chest pain, or erections lasting more than 4 hours (priapism). Seek immediate medical attention if these occur.
• This treatment is prescribed only after a licensed provider reviews your medical history and determines it is appropriate for you.